AUTHOR=Xiao Xinyi , Wang Yazhuo , Zou Zhengbang , Yang Yufei , Wang Xinyu , Xin Xin , Tu Sanfang , Li Yuhua TITLE=Combination strategies to optimize the efficacy of chimeric antigen receptor T cell therapy in haematological malignancies JOURNAL=Frontiers in Immunology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.954235 DOI=10.3389/fimmu.2022.954235 ISSN=1664-3224 ABSTRACT=
Chimeric antigen receptor (CAR) T cell therapy has revolutionized the therapeutic landscape of haematological malignancies. However, resistance and relapse remain prominent limitations, and they are related to the limited persistence and efficacy of CAR T cells, downregulation or loss of tumour antigens, intrinsic resistance of tumours to death signalling, and immune suppressive microenvironment. Rational combined modality treatments are regarded as a promising strategy to further unlock the antitumor potential of CAR T cell therapy, which can be applied before CAR T cell infusion as a conditioning regimen or in