AUTHOR=Ponciano-Gómez Alberto , Valle-Solis Martha Iris , Campos-Aguilar Myriam , Jijón-Lorenzo Rafael , Herrera-Cogco Elena de la C. , Ramos-Alor Roberto , Bazán-Mendez César Isaac , Cervantes Gustavo Antonio Pérez-Gil , Ávila-García Ricardo , Aguilar Abdiel González , Texale Moises Geovani Salmerón , Tapia-Sánchez Wilfrido David , Duarte-Martínez Carlos Leonardo , Olivas-Quintero Sandra , Sigrist-Flores Santiago Cristobal , Gallardo-Ortíz Itzell Alejandrina , Villalobos-Molina Rafael , Méndez-Cruz Adolfo Rene , Jimenez-Flores Rafael , Santos-Argumedo Leopoldo , Luna-Arias Juan Pedro , Romero-Ramírez Hector , Rosales-García Victor Hugo , Avendaño-Borromeo Bartolo TITLE=High baseline expression of IL-6 and IL-10 decreased CCR7 B cells in individuals with previous SARS-CoV-2 infection during BNT162b2 vaccination JOURNAL=Frontiers in Immunology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.946770 DOI=10.3389/fimmu.2022.946770 ISSN=1664-3224 ABSTRACT=

The current pandemic generated by SARS-CoV-2 has led to mass vaccination with different biologics that have shown wide variations among human populations according to the origin and formulation of the vaccine. Studies evaluating the response in individuals with a natural infection before vaccination have been limited to antibody titer analysis and evaluating a few humoral and cellular response markers, showing a more rapid and intense humoral response than individuals without prior infection. However, the basis of these differences has not been explored in depth. In the present work, we analyzed a group of pro and anti-inflammatory cytokines, antibody titers, and cell populations in peripheral blood of individuals with previous SARS-CoV-2 infection using BNT162b2 biologic. Our results suggest that higher antibody concentration in individuals with an earlier disease could be generated by higher production of plasma cells to the detriment of the presence of memory B cells in the bloodstream, which could be related to the high baseline expression of cytokines (IL-6 and IL-10) before vaccination.