AUTHOR=Codolo Gaia , Coletta Sara , D’Elios Mario Milco , de Bernard Marina 

TITLE=HP-NAP of Helicobacter pylori: The Power of the Immunomodulation

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.944139

DOI=10.3389/fimmu.2022.944139

ISSN=1664-3224

ABSTRACT=<p>The miniferritin HP-NAP of <italic>Helicobacter pylori</italic> was originally described as a neutrophil-activating protein because of the capacity to activate neutrophils to generate oxygen radicals and adhere to endothelia. Currently, the main feature for which HP-NAP is known is the ability to promote Th1 responses and revert the immune suppressive profile of macrophages. In this review, we discuss the immune modulating properties of the protein regarding the <italic>H. pylori</italic> infection and the evidence that support the potential clinical application of HP-NAP in allergy and cancer immunotherapy.</p>