AUTHOR=Kawashima-Vasconcelos Marianna Y. , Santana-Gonçalves Maynara , Zanin-Silva Djúlio C. , Malmegrim Kelen C. R. , Oliveira Maria Carolina 

TITLE=Reconstitution of the immune system and clinical correlates after stem cell transplantation for systemic sclerosis

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.941011

DOI=10.3389/fimmu.2022.941011

ISSN=1664-3224

ABSTRACT=<p>Systemic sclerosis (SSc) is a chronic autoimmune disease that includes fibrosis, diffuse vasculopathy, inflammation, and autoimmunity. Autologous hematopoietic stem cell transplantation (auto-HSCT) is considered for patients with severe and progressive SSc. In recent decades, knowledge about patient management and clinical outcomes after auto-HSCT has significantly improved. Mechanistic studies have contributed to increasing the comprehension of how profound and long-lasting are the modifications to the immune system induced by transplantation. This review revisits the immune monitoring studies after auto-HSCT for SSc patients and how they relate to clinical outcomes. This understanding is essential to further improve clinical applications of auto-HSCT and enhance patient outcomes.</p>