AUTHOR=van Geffen Chiel , Heiss Constantin , Deißler Astrid , Kolahian Saeed 

TITLE=Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.933847

DOI=10.3389/fimmu.2022.933847

ISSN=1664-3224

ABSTRACT=<p>Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population with potent suppressive and regulative properties. MDSCs’ strong immunosuppressive potential creates new possibilities to treat chronic inflammation and autoimmune diseases or induce tolerance towards transplantation. Here, we summarize and critically discuss different pharmacological approaches which modulate the generation, activation, and recruitment of MDSCs <italic>in vitro</italic> and <italic>in vivo</italic>, and their potential role in future immunosuppressive therapy.</p>