AUTHOR=Dong Hanbing , Zhang Yue , Huang Yu , Deng Hui 

TITLE=Pathophysiology of RAGE in inflammatory diseases

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.931473

DOI=10.3389/fimmu.2022.931473

ISSN=1664-3224

ABSTRACT=<p>The receptor for advanced glycation end products (RAGE) is a non-specific multi-ligand pattern recognition receptor capable of binding to a range of structurally diverse ligands, expressed on a variety of cell types, and performing different functions. The ligand-RAGE axis can trigger a range of signaling events that are associated with diabetes and its complications, neurological disorders, cancer, inflammation and other diseases. Since RAGE is involved in the pathophysiological processes of many diseases, targeting RAGE may be an effective strategy to block RAGE signaling.</p>