AUTHOR=Ma Ning , Liu Huihui , Zhang Yang , Liu Wei , Liang Zeyin , Wang Qian , Sun Yuhua , Wang Lihong , Li Yuan , Ren Hanyun , Dong Yujun TITLE=Identification of CD8+ T-cell epitope from multiple myeloma-specific antigen AKAP4 JOURNAL=Frontiers in Immunology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.927804 DOI=10.3389/fimmu.2022.927804 ISSN=1664-3224 ABSTRACT=
Multiple myeloma (MM) is a malignant plasma cell disorder affecting mainly the elderly population. Revolutionary progress in immunotherapy has been made recently, including monoclonal antibodies and chimeric antigen receptor T cell (CAR-T) therapies; however, the high relapse rate remains problematic. Therefore, combination therapies against different targets would be a reasonable strategy. In this study, we present a new X-chromosome encoded testis-cancer antigen (CTA) AKAP4 as a potential target for MM. AKAP4 is expressed in MM cell lines and MM primary malignant plasma cells. HLA-A*0201-restricted cytotoxic T lymphocytes (CTLs) induced by dendritic cells (DCs) transduced with an adenovirus vector encoding the full-length