AUTHOR=Tang Xiaoxuan , Li Qiaoyuan , Huang Tingting , Zhang Han , Chen Xiaoli , Ling Jue , Yang Yumin 

TITLE=Regenerative Role of T Cells in Nerve Repair and Functional Recovery

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.923152

DOI=10.3389/fimmu.2022.923152

ISSN=1664-3224

ABSTRACT=<p>The immune system is essential in the process of nerve repair after injury. Successful modulation of the immune response is regarded as an effective approach to improving treatment outcomes. T cells play an important role in the immune response of the nervous system, and their beneficial roles in promoting regeneration have been increasingly recognized. However, the diversity of T-cell subsets also delivers both neuroprotective and neurodegenerative functions. Therefore, this review mainly discusses the beneficial impact of T-cell subsets in the repair of both peripheral nervous system and central nervous system injuries and introduces studies on various therapies based on T-cell regulation. Further discoveries in T-cell mechanisms and multifunctional biomaterials will provide novel strategies for nerve regeneration.</p>