AUTHOR=Zhao Zi-Yue , Chen Zhuo-Yuan , Yu Bin , Xiao Bo , Liu Li-Yan , Xia Yu , Li Ao-Yu , Wang Ping-Xiao , Xiang Cheng , Liu Chao , Yang Hui-Qin , Li Hui , Xiao Tao TITLE=Characterization of the immune cell infiltration landscape in myxofibrosarcoma to aid immunotherapy JOURNAL=Frontiers in Immunology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.916915 DOI=10.3389/fimmu.2022.916915 ISSN=1664-3224 ABSTRACT=

Myxofibrosarcoma (MFS) is a highly malignant subtype of soft tissue sarcoma, accounting for 5% of cases. Immunotherapy guided by immune cell infiltration (ICI) is reportedly a promising treatment strategy. Here, MFS samples (n = 104) from two independent databases were classified as ICI clusters A/B/C and gene clusters A/B/C. Then, a close relationship between ICI and gene clusters was established. We found that the features of these clusters were consistent with the characteristics of immune-inflamed tumors (cluster C), immune-desert tumors (cluster B), and immune-excluded tumors (cluster A). Moreover, cluster C was sensitive to immunotherapy. Finally, an independent ICI score was established to predict the therapeutic effect, which has prospects for application in guiding immunotherapy during clinical practice.