AUTHOR=Huang Ziyu , Chu Ming , Chen Xi , Wang Ziyuan , Jiang Lin , Ma Yinchao , Wang Yuedan 

TITLE=Th2A cells: The pathogenic players in allergic diseases

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.916778

DOI=10.3389/fimmu.2022.916778

ISSN=1664-3224

ABSTRACT=<p>Proallergic type 2 helper T (Th2A) cells are a subset of memory Th2 cells confined to atopic individuals, and they include all the allergen-specific Th2 cells. Recently, many studies have shown that Th2A cells characterized by CD3<sup>+</sup> CD4<sup>+</sup> HPGDS<sup>+</sup> CRTH2<sup>+</sup> CD161<sup>high</sup> ST2<sup>high</sup> CD49d<sup>high</sup> CD27<sup>low</sup> play a crucial role in allergic diseases, such as atopic dermatitis (AD), food allergy (FA), allergic rhinitis (AR), asthma, and eosinophilic esophagitis (EoE). In this review, we summarize the discovery, biomarkers, and biological properties of Th2A cells to gain new insights into the pathogenesis of allergic diseases.</p>