AUTHOR=Tang Yunping , Pu Qiuyan , Zhao Qiaoling , Zhou Yafeng , Jiang Xiaoxia , Han Tao 

TITLE=Effects of Fucoidan Isolated From Laminaria japonica on Immune Response and Gut Microbiota in Cyclophosphamide-Treated Mice

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.916618

DOI=10.3389/fimmu.2022.916618

ISSN=1664-3224

ABSTRACT=<p>The effects of <italic>Laminaria japonica</italic> fucoidan (LF) on immune regulation and intestinal microflora in cyclophosphamide (CTX)-treated mice were investigated in this work. Results indicated that LF significantly enhanced the spleen and thymus indices, promoted spleen lymphocyte and peritoneal macrophages proliferation, and increased the immune-related cytokines production in serum. Moreover, LF could regulate intestinal flora composition, increasing the abundance of <italic>Lactobacillaceae</italic> and <italic>Alistipes</italic>, and inhibiting <italic>Erysipelotrichia</italic>, <italic>Turicibacter</italic>, <italic>Romboutsia</italic>, <italic>Peptostreptococcaceae</italic>, and <italic>Faecalibaculum</italic>. These results were positively correlated with immune characteristics. Overall, LF could be useful as a new potential strategy to mitigate CTX immunosuppression and intestinal microbiota disorders.</p>