AUTHOR=He Yufei , Liu Jia , Chen Yutong , Yan Lan , Wu Jianhua 

TITLE=Neutrophil Extracellular Traps in Candida albicans Infection

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.913028

DOI=10.3389/fimmu.2022.913028

ISSN=1664-3224

ABSTRACT=<p><italic>Candida albicans</italic> is the most common pathogen causing clinical <italic>Candida</italic> infections. Neutrophils are a key member of the host innate immunity that plays an essential role in clearing invading <italic>C. albicans</italic>. In addition to the well-known defensive approaches such as phagocytosis, degranulation, and reactive oxygen species production, the formation of neutrophil extracellular traps (NETs) has also become an important way for neutrophils to defend against various pathogens. <italic>C. albicans</italic> has been reported to be capable of activating neutrophils to release NETs that subsequently kill fungi. The induction of NETs is affected by both the morphology and virulence factors of <italic>C. albicans</italic>, which also develops specific strategies to respond to the attack by NETs. Our review specifically focuses on the mechanisms by which <italic>C. albicans</italic> triggers NET formation and their subsequent interactions, which might provide meaningful insight into the innate immunity against <italic>C. albicans</italic> infection.</p>