AUTHOR=Guo Ye , Guo Hanfei , Zhang Yongfei , Cui Jiuwei 

TITLE=Anaplastic lymphoma kinase-special immunity and immunotherapy

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.908894

DOI=10.3389/fimmu.2022.908894

ISSN=1664-3224

ABSTRACT=<p>Alterations in the anaplastic lymphoma kinase (<italic>ALK</italic>) gene play a key role in the development of various human tumors, and targeted therapy has transformed the treatment paradigm for these oncogene-driven tumors. However, primary or acquired resistance remains a challenge. <italic>ALK</italic> gene variants (such as gene rearrangements and mutations) also play a key role in the tumor immune microenvironment. Immunotherapy targeting the <italic>ALK</italic> gene has potential clinical applications. Here, we review the results of recent studies on the immunological relevance of ALK-altered tumors, which provides important insights into the development of tumor immunotherapies targeting this large class of tumors.</p>