AUTHOR=Dürholz Kerstin , Schmid Eva , Frech Michael , Azizov Vugar , Otterbein Nadine , Lucas Sébastien , Rauh Manfred , Schett Georg , Bruns Heiko , Zaiss Mario M. TITLE=Microbiota-Derived Propionate Modulates Megakaryopoiesis and Platelet Function JOURNAL=Frontiers in Immunology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.908174 DOI=10.3389/fimmu.2022.908174 ISSN=1664-3224 ABSTRACT=
Rheumatoid arthritis (RA) is associated with an increased risk for cardiovascular events driven by abnormal platelet clotting effects. Platelets are produced by megakaryocytes, deriving from megakaryocyte erythrocyte progenitors (MEP) in the bone marrow. Increased megakaryocyte expansion across common autoimmune diseases was shown for RA, systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS). In this context, we evaluated the role of the microbial-derived short chain fatty acid (SCFA) propionate on hematopoietic progenitors in the collagen induced inflammatory arthritis model (CIA) as we recently showed attenuating effects of preventive propionate treatment on CIA severity.