AUTHOR=Bocharov Gennady , Grebennikov Dmitry , Cebollada Rica Paula , Domenjo-Vila Eva , Casella Valentina , Meyerhans Andreas 

TITLE=Functional cure of a chronic virus infection by shifting the virus - host equilibrium state

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.904342

DOI=10.3389/fimmu.2022.904342

ISSN=1664-3224

ABSTRACT=<p>The clinical handling of chronic virus infections remains a challenge. Here we describe recent progress in the understanding of virus - host interaction dynamics. Based on the systems biology concept of multi-stability and the prediction of multiplicative cooperativity between virus-specific cytotoxic T cells and neutralising antibodies, we argue for the requirements to engage multiple immune system components for functional cure strategies. Our arguments are derived from LCMV model system studies and are translated to HIV-1 infection.</p>