AUTHOR=Anwar Imran J. , DeLaura Isabel F. , Gao Qimeng , Ladowski Joseph , Jackson Annette M. , Kwun Jean , Knechtle Stuart J. 

TITLE=Harnessing the B Cell Response in Kidney Transplantation – Current State and Future Directions

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.903068

DOI=10.3389/fimmu.2022.903068

ISSN=1664-3224

ABSTRACT=<p>Despite dramatic improvement in kidney transplantation outcomes over the last decades due to advent of modern immunosuppressive agents, long-term outcomes remain poor. Antibody-mediated rejection (ABMR), a B cell driven process, accounts for the majority of chronic graft failures. There are currently no FDA-approved regimens for ABMR; however, several clinical trials are currently on-going. In this review, we present current mechanisms of B cell response in kidney transplantation, the clinical impact of sensitization and ABMR, the B cell response under current immunosuppressive regimens, and ongoing clinical trials for ABMR and desensitization treatment.</p>