AUTHOR=Baumann Ulrich , Schulte Johannes H. , Groß Jonathan P. , Beier Rita , Ludwig Marius , Wahn Volker , Hofmann Jörg , Maecker-Kolhoff Britta , Sauer Martin , Kaiser-Labusch Petra , Karimian Negin , Blume-Peytavi Ulrike , Ghoreschi Franziska , Ott Hagen , Perelygina Ludmila , Klemann Christian , Blankenstein Oliver , von Bernuth Horst , Krüger Renate 

TITLE=Case Report: Rubella Virus-Induced Cutaneous Granulomas in Two Pediatric Patients With DNA Double Strand Breakage Repair Disorders – Outcome After Hematopoietic Stem Cell Transplantation

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.886540

DOI=10.3389/fimmu.2022.886540

ISSN=1664-3224

ABSTRACT=<p>We report two patients with DNA repair disorders (Artemis deficiency, Ataxia telangiectasia) with destructive skin granulomas, presumably triggered by live-attenuated rubella vaccinations. Both patients showed reduced naïve T cells. Rapid resolution of skin lesions was observed following hematopoietic stem cell transplantation. However, the patient with AT died due to complications of severe hepatic veno-occlusive disease 6 month after HSCT. Dried blood spots obtained after birth were available from this patient and showed absent T-cell receptor excision circles (TRECs). Therefore, newborn screening may help to prevent patients with moderate T-cell deficiency from receiving live-attenuated rubella vaccine potentially causing granulomas.</p>