AUTHOR=Belmonte Beatrice , Mangogna Alessandro , Gulino Alessandro , Cancila Valeria , Morello Gaia , Agostinis Chiara , Bulla Roberta , Ricci Giuseppe , Fraggetta Filippo , Botto Marina , Garred Peter , Tedesco Francesco TITLE=Distinct Roles of Classical and Lectin Pathways of Complement in Preeclamptic Placentae JOURNAL=Frontiers in Immunology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.882298 DOI=10.3389/fimmu.2022.882298 ISSN=1664-3224 ABSTRACT=
Pre-eclampsia is a pregnancy complication characterized by defective vascular remodeling in maternal decidua responsible for reduced blood flow leading to functional and structural alterations in the placenta. We have investigated the contribution of the complement system to decidual vascular changes and showed that trophoblasts surrounding unremodeled vessels prevalent in preeclamptic decidua fail to express C1q that are clearly detected in cells around remodeled vessels predominant in control placenta. The critical role of C1q is supported by the finding that decidual trophoblasts of female