AUTHOR=Sanchez Clemente Nuria , Penner Justin , Breuer Judith , Ip Winnie , Booth Claire TITLE=Case Report: A Severe Paediatric Presentation of COVID-19 in APDS2 Immunodeficiency JOURNAL=Frontiers in Immunology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.881259 DOI=10.3389/fimmu.2022.881259 ISSN=1664-3224 ABSTRACT=

Critical respiratory manifestations of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are rare in children, and little is known about how immunocompromised children respond to the infection. We report a case of a 4-year-old boy with activated PI3K delta syndrome type 2 (APDS2) with a protracted and severe COVID-19 course with both inflammatory and acute respiratory features. He was treated with remdesivir, nitazoxanide, high-dose corticosteroids, and tocilizumab and made a full recovery. We propose that remdesivir may be used in combination with nitazoxanide to improve viral clearance and reduce the chance of resistance in treating acute SARS-CoV-2 infection.