AUTHOR=Murase Yuya , Takeichi Takuya , Koseki Jun , Miyasaka Yuki , Muro Yoshinao , Ohno Tamio , Shimamura Teppei , Akiyama Masashi TITLE=UVB-Induced Skin Autoinflammation Due to Nlrp1b Mutation and Its Inhibition by Anti-IL-1β Antibody JOURNAL=Frontiers in Immunology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.876390 DOI=10.3389/fimmu.2022.876390 ISSN=1664-3224 ABSTRACT=
NLRP1 (NACHT and leucine-rich repeat-containing protein family, pyrin domain-containing protein 1) is an innate immune sensor that is involved in the formation of inflammasome complexes. NLRP1 hyperactivity has been reported to cause inherited autoinflammatory diseases including familial keratosis lichenoides chronica and NLRP1-associated autoinflammation with arthritis and dyskeratosis. We generated