AUTHOR=Thome Aaron D. , Thonhoff Jason R. , Zhao Weihua , Faridar Alireza , Wang Jinghong , Beers David R. , Appel Stanley H. TITLE=Extracellular Vesicles Derived From Ex Vivo Expanded Regulatory T Cells Modulate In Vitro and In Vivo Inflammation JOURNAL=Frontiers in Immunology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.875825 DOI=10.3389/fimmu.2022.875825 ISSN=1664-3224 ABSTRACT=
Extracellular vehicles (EVs) are efficient biomarkers of disease and participate in disease pathogenesis; however, their use as clinical therapies to modify disease outcomes remains to be determined. Cell-based immune therapies, including regulatory T cells (Tregs), are currently being clinically evaluated for their usefulness in suppressing pro-inflammatory processes. The present study demonstrates that