AUTHOR=Zaffina Salvatore , Piano Mortari Eva , Di Prinzio Reparata Rosa , Cappa Marco , Novelli Antonio , Agolini Emanuele , Raponi Massimiliano , Dallapiccola Bruno , Locatelli Franco , Perno Carlo Federico , Carsetti Rita 

TITLE=Case Report: Precision COVID-19 Immunization Strategy to Overcome Individual Fragility: A Case of Generalized Lipodystrophy Type 4

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.869042

DOI=10.3389/fimmu.2022.869042

ISSN=1664-3224

ABSTRACT=<p>A 48-year-old patient affected with congenital generalized lipodystrophy type 4 failed to respond to two doses of the BNT162b2 vaccine, consisting of lipid nanoparticle encapsulated mRNA. As the disease is caused by biallelic variants of <italic>CAVIN1</italic>, a molecule indispensable for lipid endocytosis and regulation, we complemented the vaccination cycle with a single dose of the Ad26.COV2 vaccine. Adenovirus-based vaccine entry is mediated by the interaction with adenovirus receptors and transport occurs in clathrin-coated pits. Ten days after Ad26.COV2 administration, S- and RBD-specific antibodies and high-affinity memory B cells increased significantly to values close to those observed in Health Care Worker controls.</p>