AUTHOR=Keep Sarah , Carr Brigid Veronica , Lean Fabian Z. X. , Fones Albert , Newman Joseph , Dowgier Giulia , Freimanis Graham , Vatzia Eleni , Polo Noemi , Everest Holly , Webb Isobel , Mcnee Adam , Paudyal Basu , Thakur Nazia , Nunez Alejandro , MacLoughlin Ronan , Maier Helena , Hammond John , Bailey Dalan , Waters Ryan , Charleston Bryan , Tuthill Toby , Britton Paul , Bickerton Erica , Tchilian Elma TITLE=Porcine Respiratory Coronavirus as a Model for Acute Respiratory Coronavirus Disease JOURNAL=Frontiers in Immunology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.867707 DOI=10.3389/fimmu.2022.867707 ISSN=1664-3224 ABSTRACT=
In the light of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, we have developed a porcine respiratory coronavirus (PRCV) model for in depth mechanistic evaluation of the pathogenesis, virology and immune responses of this important family of viruses. Pigs are a large animal with similar physiology and immunology to humans and are a natural host for PRCV. Four PRCV strains were investigated and shown to induce different degrees of lung pathology. Importantly, although all four strains replicated equally well in porcine cell lines