AUTHOR=Dai Xiaofeng , Ye Yongju , He Fule 

TITLE=Emerging innovations on exosome-based onco-therapeutics

JOURNAL=Frontiers in Immunology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.865245

DOI=10.3389/fimmu.2022.865245

ISSN=1664-3224

ABSTRACT=Exosomes are nanosized extracellular vesicles secreted by various sources for intercellular communications. They pertain numerous cargos and functionalities from parental cells, and are featured by enhanced stability and flexibility that render their massive ex vivo production and in situ application feasible. Exosome is rapidly gaining momentum as a novel strategy for the diagnosis and therapeutics of a spectrum of diseases, as evidenced by the surging number of scientific publications, clinical trials and industrial financial activities within recent years. This paper focuses on cancer therapeutics, characterizes exosomes into two clinically relevant applications, i.e., immune-therapeutics and drug delivery, reviews current innovations based on exosomes, and casts our insights on how cold atmospheric plasma, an emerging anti-cancer strategy, may aid in the conceptual and technological innovations in exosome-based onco-therapeutics towards our improved power over cancers.