AUTHOR=Höglund Julia , Hadizadeh Fatemeh , Ek Weronica E. , Karlsson Torgny , Johansson Åsa TITLE=Gene-Based Variant Analysis of Whole-Exome Sequencing in Relation to Eosinophil Count JOURNAL=Frontiers in Immunology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.862255 DOI=10.3389/fimmu.2022.862255 ISSN=1664-3224 ABSTRACT=
Eosinophils play important roles in the release of cytokine mediators in response to inflammation. Many associations between common genetic variants and eosinophils have already been reported, using single nucleotide polymorphism (SNP) array data. Here, we have analyzed 200,000 whole-exome sequences (WES) from the UK Biobank cohort and performed gene-based analyses of eosinophil count. We defined five different variant weighting schemes to incorporate information on both deleteriousness and frequency. A total of 220 genes in 55 distinct (>10 Mb apart) genomic regions were found to be associated with eosinophil count, of which seven genes (