AUTHOR=Joudi Anthony M. , Reyes Flores Carla P. , Singer Benjamin D. 

TITLE=Epigenetic Control of Regulatory T Cell Stability and Function: Implications for Translation

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.861607

DOI=10.3389/fimmu.2022.861607

ISSN=1664-3224

ABSTRACT=<p>FoxP3<sup>+</sup> regulatory T (Treg) cells maintain immune homeostasis, promote self-tolerance, and have an emerging role in resolving acute inflammation, providing tissue protection, and repairing tissue damage. Some data suggest that FoxP3<sup>+</sup> T cells are plastic, exhibiting susceptibility to losing their function in inflammatory cytokine-rich microenvironments and paradoxically contributing to inflammatory pathology. As a result, plasticity may represent a barrier to Treg cell immunotherapy. Here, we discuss controversies surrounding Treg cell plasticity and explore determinants of Treg cell stability in inflammatory microenvironments, focusing on epigenetic mechanisms that clinical protocols could leverage to enhance efficacy and limit toxicity of Treg cell-based therapeutics.</p>