AUTHOR=Tarannum Mubin , Romee Rizwan , Shapiro Roman M. 

TITLE=Innovative Strategies to Improve the Clinical Application of NK Cell-Based Immunotherapy

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.859177

DOI=10.3389/fimmu.2022.859177

ISSN=1664-3224

ABSTRACT=<p>Natural killer cells constitute a part of the innate immune system that mediates an effective immune response towards virus-infected and malignant cells. In recent years, research has focused on exploring and advancing NK cells as an active immunotherapy platform. Despite major advances, there are several key challenges that need to be addressed for the effective translation of NK cell research to clinical applications. This review highlights some of these challenges and the innovative strategies being developed to overcome them, including <italic>in vitro</italic> expansion, <italic>in vivo</italic> persistence, infiltration to the tumor site, and prevention of exhaustion.</p>