AUTHOR=dos Passos Junior Rinaldo Rodrigues , Bomfim Gisele Facholi , Giachini Fernanda R. , Tostes Rita C. , Lima Victor Vitorino 

TITLE=O-Linked β-N-Acetylglucosamine Modification: Linking Hypertension and the Immune System

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.852115

DOI=10.3389/fimmu.2022.852115

ISSN=1664-3224

ABSTRACT=<p>The <italic>O</italic>-linked β-<italic>N</italic>-acetylglucosamine modification (O-GlcNAcylation) of proteins dynamically regulates protein function, localization, stability, and interactions. This post-translational modification is intimately linked to cardiovascular disease, including hypertension. An increasing number of studies suggest that components of innate and adaptive immunity, active players in the pathophysiology of hypertension, are targets for O-GlcNAcylation. In this review, we highlight the potential roles of O-GlcNAcylation in the immune system and discuss how those immune targets of O-GlcNAcylation may contribute to arterial hypertension.</p>