AUTHOR=Donnenberg Vera S. , Wagner Patrick L. , Luketich James D. , Bartlett David L. , Donnenberg Albert D. 

TITLE=Localized Intra-Cavitary Therapy to Drive Systemic Anti-Tumor Immunity

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.846235

DOI=10.3389/fimmu.2022.846235

ISSN=1664-3224

ABSTRACT=<p>Metastasis to the pleural and peritoneal cavities is a common terminal pathway for a wide variety of cancers. This article explores how these unique environments both promote aggressive tumor behavior and suppresses anti-tumor immunity, and ways in which local delivery of protein therapeutics can leverage the contained nature of these spaces to a therapeutic advantage, achieving high intra-cavital concentrations while minimizing systemic toxicity.</p>