AUTHOR=Chen Chunyue , Xia Congcong , Tang Hao , Jiang Yirun , Wang Shan , Zhang Xin , Huang Tao , Yuan Xiaoqing , Wang Junpu , Peng Li 

TITLE=Circular RNAs Involve in Immunity of Digestive Cancers From Bench to Bedside: A Review

JOURNAL=Frontiers in Immunology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.833058

DOI=10.3389/fimmu.2022.833058

ISSN=1664-3224

ABSTRACT=The immune system plays a complex role in tumour formation and development. On the one hand, immune surveillance can inhibit the growth of tumours; on the other hand, immune evasion of tumours can create conditions conducive for tumour development and growth. CircRNAs are endogenous noncoding RNAs with a covalently closed loop structure that are abundantly expressed in eukaryotic organisms and are characterized by stable structure, rich diversity, and high evolutionary conservation. In particular, circRNAs play a vital role in the occurrence, development, and treatment of tumours through its unique functions. Recently, the incidence and mortality of digestive cancers, especially those of gastric cancer, colorectal cancer, and liver cancer, have remained high.  However, the functions of circRNAs in digestive cancers cancer immunity are less known. The relationship between circRNAs and digestive tumour immunity is systematically discussed in our paper for the first time. CircRNA can influence the immune microenvironment of gastrointestinal tumours to promote their occurrence and development by acting as a miRNA molecular sponge, interacting with proteins, and regulating selective splicing. The circRNA vaccine even provides a new idea for tumour immunotherapy. Future studies should be focused on the location, transportion, and degradation mechanisms of circRNA in living cells and the relationship between circRNA and tumour immunity. This paper provides a new idea for the diagnosis and treatment of gastrointestinal tumors.