AUTHOR=Hosseinian Sina , Powers Kathleen , Vasudev Milind , Palma Anton M. , de Assis Rafael , Jain Aarti , Horvath Peter , Birring Paramveer S. , Andary Rana , Au Connie , Chin Brandon , Khalil Ghali , Ventura Jenny , Luu Madeleine K. , Figueroa Cesar , Obiero Joshua M. , Silzel Emily , Nakajima Rie , Gombrich William Thomas , Jasinskas Algis , Zaldivar Frank , Schubl Sebastian , Felgner Philip L. , Khan Saahir , The Specimen Collection Group TITLE=Persistence of SARS-CoV-2 Antibodies in Vaccinated Health Care Workers Analyzed by Coronavirus Antigen Microarray JOURNAL=Frontiers in Immunology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.817345 DOI=10.3389/fimmu.2022.817345 ISSN=1664-3224 ABSTRACT=

Recent studies provide conflicting evidence on the persistence of SARS-CoV-2 immunity induced by mRNA vaccines. Here, we aim to quantify the persistence of humoral immunity following vaccination using a coronavirus antigen microarray that includes 10 SARS-CoV-2 antigens. In a prospective longitudinal cohort of 240 healthcare workers, composite SARS-CoV-2 IgG antibody levels did not wane significantly over a 6-month study period. In the subset of the study population previously exposed to SARS-CoV-2 based on seropositivity for nucleocapsid antibodies, higher composite anti-spike IgG levels were measured before the vaccine but no significant difference from unexposed individuals was observed at 6 months. Age, vaccine type, or worker role did not significantly impact composite IgG levels, although non-significant trends towards lower antibody levels in older participants and higher antibody levels with Moderna vaccine were observed at 6 months. A small subset of our cohort were classified as having waning antibody titers at 6 months, and these individuals were less likely to work in patient care roles and more likely to have prior exposure to SARS-CoV-2.