AUTHOR=Humeau Mélanie , Boniface Katia , Bodet Charles 

TITLE=Cytokine-Mediated Crosstalk Between Keratinocytes and T Cells in Atopic Dermatitis

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.801579

DOI=10.3389/fimmu.2022.801579

ISSN=1664-3224

ABSTRACT=<p>Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by barrier dysfunction, dysregulated immune response, and dysbiosis with increased <italic>Staphylococcus aureus</italic> colonization. Infiltration of various T helper cell subsets into lesional skin and subsequent cytokine release are a hallmark of AD. Release of cytokines by both T cells and keratinocytes plays a key role in skin inflammation and drives many AD features. This review aims to discuss cytokine-mediated crosstalk between T cells and keratinocytes in AD pathogenesis and the potential impact of virulence factors produced by <italic>Staphylococcus aureus</italic> on these interactions.</p>