AUTHOR=Juanes-Velasco Pablo , Landeira-Viñuela Alicia , García-Vaquero Marina L. , Lecrevisse Quentin , Herrero Raquel , Ferruelo Antonio , Góngora Rafael , Corrales Fernando , Rivas Javier De Las , Lorente Jose A. , Hernández Ángela-Patricia , Fuentes Manuel TITLE=SARS-CoV-2 Infection Triggers Auto-Immune Response in ARDS JOURNAL=Frontiers in Immunology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.732197 DOI=10.3389/fimmu.2022.732197 ISSN=1664-3224 ABSTRACT=

Acute respiratory distress syndrome (ARDS) is a severe pulmonary disease, which is one of the major complications in COVID-19 patients. Dysregulation of the immune system and imbalances in cytokine release and immune cell activation are involved in SARS-CoV-2 infection. Here, the inflammatory, antigen, and auto-immune profile of patients presenting COVID-19-associated severe ARDS has been analyzed using functional proteomics approaches. Both, innate and humoral responses have been characterized through acute-phase protein network and auto-antibody signature. Severity and sepsis by SARS-CoV-2 emerged to be correlated with auto-immune profiles of patients and define their clinical progression, which could provide novel perspectives in therapeutics development and biomarkers of COVID-19 patients. Humoral response in COVID-19 patients’ profile separates with significant differences patients with or without ARDS. Furthermore, we found that this profile can be correlated with COVID-19 severity and results more common in elderly patients.