AUTHOR=Courbin Virginie , Riller Quentin , Amegnizin Jean-Louis , Gricourt Guillaume , Demontant Vanessa , Fihman Vincent , Angebault Cecile , Mahevas Matthieu , Gaube Géraldine , Coutte Laëtitia , Pawlotsky Jean-Michel , Lepeule Raphaël , Rodriguez Christophe , Woerther Paul-Louis TITLE=Case Report: Cerebral Nocardiosis Caused by Nocardia cyriacigeorgica Detected by Metagenomics in an Apparently Immunocompetent Patient JOURNAL=Frontiers in Immunology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.719124 DOI=10.3389/fimmu.2022.719124 ISSN=1664-3224 ABSTRACT=

We report a case of meningoencephalitis due to Nocardia cyriacigeorgica diagnosed with metagenomics, while all the standard methods were negative. This diagnosis made adaptation of antimicrobial treatment possible and led to the discovery of a rare, acquired immunodeficiency syndrome.