AUTHOR=Kao Chien-Hsiang , Liu Chien-Ting , Lin Hao , Huang Yung-Cheng , Lan Jui , Ou Yu-Che , Fu Hung-Chun , Wu Chen-Hsuan 

TITLE=Case report: Durable response after pembrolizumab in combination with radiation - induced abscopal effect in platinum - refractory metastatic endometrial clear cell carcinoma

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.1079253

DOI=10.3389/fimmu.2022.1079253

ISSN=1664-3224

ABSTRACT=<p>Advanced endometrial clear cell carcinoma (CCC) tends to have poor prognosis owing to aggressive clinical behavior and poor response to conventional chemotherapy. Herein, we report a case of platinum-refractory recurrent ECCC successfully treated with the combination of pembrolizumab, localized radiotherapy and a few cycles of chemotherapy with an extremely durable response even after cessation of immunotherapy for 3 years at the time of publication.</p>