AUTHOR=Muñoz-Sánchez Guillermo , Planagumà Jesús , Naranjo Laura , Couso Rocío , Sabater Lidia , Guasp Mar , Martínez-Hernández Eugenia , Graus Francesc , Dalmau Josep , Ruiz-García Raquel TITLE=The diagnosis of anti-LGI1 encephalitis varies with the type of immunodetection assay and sample examined JOURNAL=Frontiers in Immunology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.1069368 DOI=10.3389/fimmu.2022.1069368 ISSN=1664-3224 ABSTRACT=
Detection of Leucine-rich glioma inactivated 1 (LGI1) antibodies in patients with suspected autoimmune encephalitis is important for diagnostic confirmation and prompt implementation of immunomodulatory treatment. However, the clinical laboratory diagnosis can be challenging. Previous reports have suggested that the type of test and patient’s sample (serum or CSF) have different clinical performances, however, there are no studies comparing different diagnostic tests on paired serum/CSF samples of patients with anti-LGI1 encephalitis. Here, we assessed the clinical performance of a commercial and an