AUTHOR=Sun Xiwen , Luo Chunyu , Tang Ru , Mao Song , Zhu Ying , Fei Chonghui , Wang Mengyu , Tan Shaolin , Zhang Shiyao , Zhou Jiayao , Lin Hai , Li Zhipeng , Zhang Weitian 

TITLE=Sinonasal diffuse large B-cell lymphoma in a patient with Wiskott–Aldrich syndrome: A case report and literature review

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.1062261

DOI=10.3389/fimmu.2022.1062261

ISSN=1664-3224

ABSTRACT=<p>Wiskott–Aldrich syndrome (WAS) is a rare primary immunodeficiency disease with a predisposition towards autoimmunity and lymphoproliferative diseases. Non-Hodgkin lymphoma (NHL) is reported to be the predominant form of malignant tumor in WAS sufferers. Diffuse large B-cell lymphoma (DLBCL) is one of the most common types of NHL while it is uncommon to occur in paranasal sinuses and especially when associated with WAS. In this article, we report a unique case of WAS associated with DLBCL in paranasal sinuses and review the major publications of WAS-related lymphomas that occurred in the head and neck area. This study extends the available therapies for WAS-related lymphomas and emphasizes the significance of recognition for sinonasal lymphomas in WAS patients presenting with sinusitis.</p>