AUTHOR=Pereda Maria A. , Hosahalli Vasanna Smitha , Desai Neha J. , Deng Victoria , Owusu-Ansah Amma , Dallas Mari H. , Pateva Irina , Dalal Jignesh 

TITLE=Case report: Daratumumab treatment in pre-transplant alloimmunization and severe hemolytic anemia

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.1055473

DOI=10.3389/fimmu.2022.1055473

ISSN=1664-3224

ABSTRACT=<p>Daratumumab, a CD38 monoclonal antibody that has been FDA-approved to treat multiple myeloma, has acquired popularity and is used off-label for both auto- and alloantibody mediated disorders, particularly in refractory/resistant circumstances. Much of the published data for its use in pediatric blood disorders has been in post-transplant autoimmune cytopenias. Here we describe three patients in whom daratumumab was used outside of post-transplant autoimmune cytopenias, highlighting further potential uses of this medication.</p>