AUTHOR=Liu Chengxin , Yang Juhua , Huang Huiting , Zhan Shaofeng , Xia Xintian 

TITLE=Case report: Nocardia gipuzkoensis infection in an immunocompetent patient diagnosed by metagenomic next-generation sequencing and whole genome sequencing

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.1053914

DOI=10.3389/fimmu.2022.1053914

ISSN=1664-3224

ABSTRACT=<p>The infection of <italic>Nocardia gipuzkoensis</italic> is a relatively uncommon form of pulmonary nocardiosis seen in clinical patients. In general, nocardiosis tends to occur in patients with immune deficiency. Here, we report a 23-year-old female who was admitted to the hospital due to cough and sputum production over 10 years, diagnosed with bronchiectasis. The <italic>N. gipuzkoensis</italic> infection was identified by metagenomic next-generation sequencing and whole genome sequencing. Imipenem/cilastatin and compound sulfamethoxazole tablets were used to control the infection and the pulmonary inflammation subsided gradually.</p>