AUTHOR=Zhao Zhenyu , Ren Jie , Xie Siping , Zou Longchun , Zhao Qianyue , Zeng Shan , Zha Dingsheng 

TITLE=Identification of biomarkers associated with CD8+ T cells in rheumatoid arthritis and their pan-cancer analysis

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.1044909

DOI=10.3389/fimmu.2022.1044909

ISSN=1664-3224

ABSTRACT=<sec><title>Introduction</title><p>Rheumatoid arthritis (RA), a prevailing chronic progressive autoimmune disease, seriously affects the patient's quality of life. However, there is still a lack of precise treatment and management methods in clinical practice. Previous studies showed that CD8+ T cells take a lead in the progression of RA.</p></sec><sec><title>Methods</title><p>Genes closely related to CD8+T cells in RA were identified through multiple RA datasets, CIBERSORT, and WGCNA algorithms. Further machine learning analysis were performed to identify CD8+T cell-related genes most closely related to RA. In addition, the relationship between these three key genes and 33 cancer species was also explored in this study.</p></sec><sec><title>Results</title><p>In this study, 10 genes were identified to be closely related to CD8+T cells in RA. Machine learning analysis identified 3 CD8+T cell-related genes most closely related to RA: CD8A, GZMA, and PRF1.</p></sec><sec><title>Discussion</title><p>Our research aims to provide new ideas for the clinical treatment of RA.</p></sec>