AUTHOR=Zhou Xu-Yue , Chen Kun , Zhang Jia-An 

TITLE=Mast cells as important regulators in the development of psoriasis

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.1022986

DOI=10.3389/fimmu.2022.1022986

ISSN=1664-3224

ABSTRACT=<p>Psoriasis is a chronic inflammatory immune skin disease mediated by genetic and environmental factors. As a bridge between innate and adaptive immunity, mast cells are involved in the initiation, development, and maintenance of psoriasis by interactions and communication with a variety of cells. The current review describes interactions of mast cells with T cells, Tregs, keratinocytes, adipocytes, and sensory neurons in psoriasis to emphasize the important role of mast cell-centered cell networks in psoriasis.</p>