AUTHOR=He Yu , Xia Ding , Tong Yonghua , Shang Haojie , Liu Xiao , Peng Ejun , Huang Qiu , Tang Kun , Chen Zhiqiang 

TITLE=Predictive value of CD3+ cells and interleukin 2 receptor in systemic inflammatory response syndrome after percutaneous nephrolithotomy

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.1017219

DOI=10.3389/fimmu.2022.1017219

ISSN=1664-3224

ABSTRACT=<sec><title>Objective</title><p>The aim of the current study was to evaluate the risk factors that influence the development of postoperative systemic inflammatory response syndrome (SIRS) after percutaneous nephrolithotomy (PCNL), including cytokines and lymphocyte subsets.</p></sec><sec><title>Methods</title><p>A total of 154 patients who underwent PCNL at our hospital between October 2019 and January 2022 were retrospectively reviewed. The development of post-PCNL SIRS was the primary endpoint of the study. Univariable analysis and multivariable logistic regression analysis were performed to identify independent risk factors of post-PCNL SIRS. A nomogram was constructed using the independent risk factors, and receiver operating characteristic (ROC) curves were drawn.</p></sec><sec><title>Results</title><p>There were 50 patients (32.5%) who developed SIRS after PCNL. In multivariate analysis, positive urine culture (odds ratio [OR], 3.556; <italic>p</italic> = 0.048), long operation time (OR, 1.011; <italic>p</italic> = 0.027), high IL-2R (OR, 1.002; <italic>p</italic> = 0.018), low percentage of CD3<sup>+</sup> cells (OR 0.931; <italic>p</italic> = 0.006), and high white blood cell (WBC) count (OR, 1.282<italic>; p</italic> = 0.044) were independent risk factors for post‐PCNL SIRS. These five significant variables were used to generate a nomogram that exhibited favorable fitting. The discrimination area under the ROC curves was 0.795.</p></sec><sec><title>Conclusions</title><p>Patients with long operation times, positive urine cultures, high interleukin 2 receptor, high white blood cell counts, and low percentages of CD3<sup>+</sup> cells may be at a higher risk of developing SIRS after PCNL. In these patients, cautious and comprehensive preoperative evaluations and appropriate treatment strategies should be considered.</p></sec>