AUTHOR=Xu QY. , Pan Q. , Wu Q. , Xin JQ. 

TITLE=Mycoplasma Bovis adhesins and their target proteins

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.1016641

DOI=10.3389/fimmu.2022.1016641

ISSN=1664-3224

ABSTRACT=<p>Bovine mycoplasmosis is an important infectious disease of cattle caused by <italic>Mycoplasma bovis</italic> (<italic>M. bovis</italic>) which poses a serious threat to the breeding industry. Adhesin is involved in the initial process of <italic>M. bovis</italic> colonization, which is closely related to the infection, cell invasion, immune escape and virulence of this pathogenic microorganism. For the reason that <italic>M. bovis</italic> lacks a cell wall, its adhesin is predominantly located on the surface of the cell membrane. The adhesins of <italic>M. bovis</italic> are usually identified by adhesion and adhesion inhibition analysis, and more than 10 adhesins have been identified so far. These adhesins primarily bind to plasminogen, fibronectin, heparin and amyloid precursor-like protein-2 of host cells. This review aims to concisely summarize the current knowledge regarding the adhesins of <italic>M. bovis</italic> and their target proteins of the host cell. Additionally, the biological characteristics of the adhesin will be briefly analyzed.</p>