AUTHOR=Wang Fang , Zhang Wenhao , Chai Ying , Wang Hanshao , Liu Zhonglong , He Yue 

TITLE=Constrast-enhanced computed tomography radiomics predicts CD27 expression and clinical prognosis in head and neck squamous cell carcinoma

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.1015436

DOI=10.3389/fimmu.2022.1015436

ISSN=1664-3224

ABSTRACT=<sec><title>Objective</title><p>This study aimed to construct a radiomics model that predicts the expression level of <italic>CD27</italic> in patients with head and neck squamous cell carcinoma (HNSCC).</p></sec><sec><title>Materials and methods</title><p>Genomic data and contrast-enhanced computed tomography (CT) images of patients with HNSCC were downloaded from the Cancer Genome Atlas and Cancer Imaging Archive for prognosis analysis, image feature extraction, and model construction. We explored the potential molecular mechanisms underlying <italic>CD27</italic> expression and its relationship with the immune microenvironment and predicted <italic>CD27</italic> mRNA expression in HNSCC tissues. Using non-invasive, CT-based radiomics technology, we generated a radiomics model and evaluated its correlation with the related genes and HNSCC prognosis.</p></sec><sec><title>Results and conclusion</title><p>The expression level of <italic>CD27</italic> in HNSCC may significantly influence the prognosis of patients with HNSCC. Radiomics based on contrast-enhanced CT is potentially effective in predicting the expression level of <italic>CD27</italic>.</p></sec>