AUTHOR=Royzman Dmytro , Peckert-Maier Katrin , Stich Lena , König Christina , Wild Andreas B. , Tauchi Miyuki , Ostalecki Christian , Kiesewetter Franklin , Seyferth Stefan , Lee Geoffrey , Eming Sabine A. , Fuchs Maximilian , Kunz Meik , Stürmer Ewa K. , Peters Eva M. J. , Berking Carola , Zinser Elisabeth , Steinkasserer Alexander TITLE=Soluble CD83 improves and accelerates wound healing by the induction of pro-resolving macrophages JOURNAL=Frontiers in Immunology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.1012647 DOI=10.3389/fimmu.2022.1012647 ISSN=1664-3224 ABSTRACT=

To facilitate the recovery process of chronic and hard-to-heal wounds novel pro-resolving treatment options are urgently needed. We investigated the pro-regenerative properties of soluble CD83 (sCD83) on cutaneous wound healing, where sCD83 accelerated wound healing not only after systemic but also after topical application, which is of high therapeutic interest. Cytokine profile analyses revealed an initial upregulation of inflammatory mediators such as TNFα and IL-1β, followed by a switch towards pro-resolving factors, including YM-1 and IL-10, both expressed by tissue repair macrophages. These cells are known to mediate resolution of inflammation and stimulate wound healing processes by secretion of growth factors such as epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF), which promote vascularization as well as fibroblast and keratinocyte differentiation. In conclusion, we have found strong wound healing capacities of sCD83 beyond the previously described role in transplantation and autoimmunity. This makes sCD83 a promising candidate for the treatment of chronic- and hard-to-heal wounds.