AUTHOR=Yang Yalong , Xu Fenghua 

TITLE=Evolving understanding of antibody-dependent enhancement (ADE) of SARS-CoV-2

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.1008285

DOI=10.3389/fimmu.2022.1008285

ISSN=1664-3224

ABSTRACT=<p>Since immune system and internal environment <italic>in vivo</italic> are large and complex, the interpretation of the observed immune effect from the perspective of a single immune cell or antibody seems a little feeble. Many studies have shown that specific antibodies against “ former” viruses have a reduced ability to neutralize “new” mutant strains. However, there is no comprehensive and clear view of whether there will be Antibody-dependent enhancement (ADE). We review the latest relevant studies, hoping to explain the ADE of SARS-CoV-2 infection sometimes observed in some patients.</p>