AUTHOR=Zhou Guanzhou , Zhang Nana , Meng Ke , Pan Fei 

TITLE=Interaction between gut microbiota and immune checkpoint inhibitor-related colitis

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.1001623

DOI=10.3389/fimmu.2022.1001623

ISSN=1664-3224

ABSTRACT=<p>Immune checkpoint inhibitors (ICIs) have become a promising therapeutic strategy for malignant tumors, improving patient prognosis, along with a spectrum of immune-related adverse events (irAEs), including gastrointestinal toxicity, ICI-related colitis (IRC), and diarrhea. The gut microbiota has been suggested as an important regulator in the pathogenesis of IRC, and microbiota modulations like probiotics and fecal microbiota transplantation have been explored to treat the disease. This review discusses the interaction between the gut microbiota and IRC, focusing on the potential pathogenic mechanisms and promising interventions. </p>