AUTHOR=Kottom Theodore J. , Carmona Eva M. , Limper Andrew H. 

TITLE=Current State of Carbohydrate Recognition and C-Type Lectin Receptors in Pneumocystis Innate Immunity

JOURNAL=Frontiers in Immunology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.798214

DOI=10.3389/fimmu.2021.798214

ISSN=1664-3224

ABSTRACT=<p><italic>Pneumocystis jirovecii</italic> is one of the most common fungal pathogens in immunocompromised individuals. Pneumocystis jirovecii pneumonia (PJP) causes a significant host immune response that is driven greatly by the organism’s cell wall components including β-glucans and major surface glycoprotein (Msg). These ligands interact with a number of C-type lectin receptors (CLRs) leading to downstream activation of proinflammatory signaling pathways. This minireview provides a brief overview summarizing known CLR/<italic>Pneumocystis</italic> interactions.</p>