AUTHOR=Gan Yu , Li Xiaoying , Han Shuangze , Liang Qi , Ma Xiaoqian , Rong Pengfei , Wang Wei , Li Wei 

TITLE=The cGAS/STING Pathway: A Novel Target for Cancer Therapy

JOURNAL=Frontiers in Immunology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.795401

DOI=10.3389/fimmu.2021.795401

ISSN=1664-3224

ABSTRACT=<p>As a DNA receptor, cyclic GMP-AMP synthase (cGAS) plays a crucial role in the immune system by recognizing abnormal DNA in the cytoplasm and activating the stimulator of interferon genes (STING) signaling pathway. This signaling cascade reaction leads to an immune response produced by type I interferon and other immune mediators. Recent advances in research have enhanced our current understanding of the potential role of the cGAS/STING pathway in anticancer therapy; however, in some cases, chronic STING activation may promote tumorigenesis. The present review article discusses the biological mechanisms of the cGAS/STING pathway, its dichotomous role in tumors, and the latest advances with respect to STING agonists and antagonists.</p>