AUTHOR=Bos Saskia , Daniëls Liesbeth , Michaux Lucienne , Vanden Bempt Isabelle , Vermeer Sascha , Woei-A-Jin FJ Sherida H , Schöffski Patrick , Weynand Birgit , Sciot Raf , Declercq Sabine , Ceulemans Laurens J. , Godinas Laurent , Verleden Geert M. , Van Raemdonck Dirk E. , Dupont Lieven J. , Vos Robin , the Leuven Lung Transplant Group , Yserbyt Jonas , Neyrinck Arne P. , Schaevers Veronique , Desschans Bruno , Claes Dirk , Denaux Karen , De Leyn Paul , Decaluwé Herbert , Van Veer Hans , Depypere Lieven , Emonds Marie-Paule TITLE=Case Report: An Unusual Course of Angiosarcoma After Lung Transplantation JOURNAL=Frontiers in Immunology VOLUME=12 YEAR=2022 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.789851 DOI=10.3389/fimmu.2021.789851 ISSN=1664-3224 ABSTRACT=

A 35-year-old woman underwent bilateral lung transplantation for primary ciliary dyskinesia and developed vascular tumors over a slow time course. Initial presentation of non-specific vascular tumors in the lungs and liver for up to 6 years after transplantation evolved toward bilateral ovarian angiosarcoma. Tumor analysis by haplotyping and human leukocyte antigen typing showed mixed donor chimerism, proving donor origin of the tumoral lesions. In retrospect, the donor became brain dead following neurosurgical complications for a previously biopsy-proven cerebral hemangioma, which is believed to have been a precursor lesion of the vascular malignancy in the recipient. Donor-transmitted tumors should always be suspected in solid organ transplant recipients in case of uncommon disease course or histology, and proper tissue-based diagnosis using sensitive techniques should be pursued.